Tula hantavirus L protein is a 250 kDa perinuclear membrane-associated protein

Tula Hantavirus Nucleocapsid Protein

Mapping of the regions involved in homotypic interactions of Tula hantavirus N protein.

Hantavirus nucleocapsid (N) protein has been suggested to form homodimers and homotrimers that are further integrated into the nucleocapsid filaments around the viral RNA. Here we report detailed mapping of the regions involved in the homotypic N protein interactions in Tula hantavirus (TULV). Peptide scan screening was used to define the interaction regions, and the mammalian two-hybrid assay ...

Desmoyokin, a 680 kDa keratinocyte plasma membrane-associated protein, is homologous to the protein encoded by human gene AHNAK.

We have obtained a monoclonal antibody (33A-3D) that specifically recognize desmoyokin, a 680 kDa desmosomal plaque protein that is well characterized in bovine muzzle epidermis. A cDNA clone (DY6, 3693 bp) was isolated by immunoscreening a mouse keratinocyte expression library with 33A-3D, and it was confirmed that DY6 has a partial coding sequence for desmoyokin. DY6 consists of highly homolo...

A rabbit erythrocyte membrane protein associated with L-lactate transport.

Chemical Labeling has been employed to attempt to identify the lactate transport protein of rabbit erythrocytes, which have a very high capacity for stereoselective lactate transport. The lactate transport protein catalyzes lactate/proton cotransport (or lactate/hydroxyl exchange) at physiological pH, as demonstrated by uphill proton fluxes induced by lactate gradients. However, lactate/lactate...

Tula hantavirus infection in a hospitalised patient, France, June 2015.

We report an infection with Tula virus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history. Clinical symptoms were limited to a fever syndrome with severe headache. The main laboratory findings included thrombocytopenia and elevated transaminase levels. Based on S (small) gene sequence analysis, the strain a...